beat365手机中文官方网站 - 网站welcome

学校主页 设为首页 加入收藏 联系我们

当前位置: beat365手机中文官方网站 师资队伍 师资介绍 正文

赵勤俭

作者:时间:2022-03-28点击数:

赵勤俭

博士,特聘教授,博士生导师

工作单位:重庆医科大学beat365手机中文官方网站

通信地址:重庆市渝中区医学院路1号

邮编:400016

电话:023-68485161

电子邮箱:zhaoqinjian@cqmu.edu.cn

          zhaoqinjian@gmail.com

教育经历:

(1) 1981.9–1986.7,北京医科大学,药物化学,学士

(2) 1986.9–1989.7,北京医科大学,药物化学,硕士

(3) 1989.9–1994.5,美国天主教大学,生物有机化学,博士

工作经历:

(1) 2021.03-至今,重庆医科大学beat365手机中文官方网站,特聘教授

(2) 2015.10-2021.12,厦门大学公共卫生学院,特聘教授、公共卫生学院副院长

(3) 2011.06-2015.10,厦门大学公共卫生学院,特聘教授

(4) 1997.07-2011.06,美国默克公司研发部,研究员、高级研究员、杰出高级研究员/科学主任

(5) 1993.11-1997.06,约翰•霍普金斯大学医学院,药理与分子科学系及生物化学系,博士后

学术简介:

自1997年起在世界著名药企默克公司从事生物药物相关的研制工作。在疫苗、治疗性蛋白的研发和生产中建立了多种关键的研究工具和质控手段。作为主要成员参与了世界第一个癌症疫苗(宫颈癌疫苗,Gardasil®)的研制全过程,负责其中部分关键工艺的研发及产品的质量控制。2010年入选中组部国家级人才,次年回国全职担任厦门大学公共卫生学院教授、博导,主要从事生物大分子药物质量分析与新型佐剂方面的研究,其优化后的铝佐剂现已成功助力国家疫苗中心自主研发的戊肝疫苗及HPV16/18双价苗(已获批上市)等国产疫苗中。由其主导研发的锌铝复合佐剂、新型双膦酸佐剂已申请5项专利,并已将其应用到重组新冠疫苗及流感疫苗研发当中。学术方面,在Science Translational Medicine、PNAS、Trends in Biotechnology等国际知名期刊共发表130余篇SCI论文,其中第一作者、共第一作者或通讯作者80余篇;作为通讯作者共发表国内(核心)期刊中文文章21篇,申请或授权专利共8项(其中中国专利6项,美国专利2项),并担任多个知名疫苗专业期刊杂志编委(npj vaccines、Human Vaccines & Immunotherapeutics)。

研究领域:

1. 新型免疫调节剂

利用活性代谢物调控机体免疫,以达到预防及治疗疾病的目的

微纳米颗粒免疫刺激剂的开发及其安全性、有效性评估

免疫调节剂在抗肿瘤及预防感染方面的机制研究

2. 生物大分子药物及疫苗制剂的质量分析

重组类病毒颗粒(virus-like particles, VLPs)

表位鉴定(Epitope identification)

体外相对效力分析(in vitrorelative potency, IVRP)

3. 新型疫苗佐剂研究

佐剂制备、理化性质鉴定

佐剂安全性、有效性评估

疫苗佐剂免疫调节机制

主持课题:

1.国家自然科学基金面上项目,32070925,基于矿化双膦酸微纳米颗粒的新型佐剂免疫作用机制研究,2021/01-2024/12,58万,在研,主持

2.国家自然科学基金重点项目,31730029,多聚化抗原诱导高效体液免疫应答的机制研究,2018/01-2022/12,250万,在研,参与(核心骨干成员)

3.国家自然科学基金面上项目,31670939,植物源多糖及寡糖引发平衡的Th1/Th2类免疫反应机制研究,2017/01-2020/12,60万,已结题,主持

4.国家自然科学基金面上项目,81471934,人乳头瘤病毒样颗粒不同中和表位的特性与结构基础研究,2015/01-2018/12,72万,已结题,主持

5.国家自然科学基金面上项目,81273327,人乳头瘤病毒样颗粒表位的鉴定和中和机制研究,2013/01-2013/12,16万,已结题,主持

6.“十二五”863重大项目,2012AA02A408,疫苗研发关键技术及产品研发,2012/01-2015/12,1600万元,已结题,主持

获得荣誉:

  1. 全国抗击新冠肺炎疫情先进集体奖(厦门大学国家传染病诊断试剂与疫苗工程技术研究中心),授予单位:中共中央、国务院、中央军委,2020年9月

  2. 求是杰出科技成就集体奖,香港求是科技基金会,2015年9月(夏宁邵,李少伟,张军,吴婷,黄守杰,李益民,葛胜祥,顾颖,郑子峥,袁权,潘晖榕,吴文翰,赵勤俭,史维国,罗文新,陈毅歆,程通,俞海)

  3. 荣获“工业生物技术奖”,授予单位:美国化学学会生物化学技术部,2006年9月

近五年代表性论文(通讯或共通讯作者):

  1. Yangtao Wu, Xiaofen Huang, Lunzhi Yuan, Shaojuan Wang, Yali Zhang, Hualong Xiong, Rirong Chen, Jian Ma, Ruoyao Qi, Meifeng Nie, Jingjing Xu, Zhigang Zhang, Liqiang Chen, Min Wei, Ming Zhou, Minping Cai, Yang Shi, Liang Zhang, Huan Yu, Junping Hong, Zikang Wang, Yunda Hong, Mingxi Yue, Zonglin Li, Dabing Chen, Qingbing Zheng, Shaowei Li, Yixin Chen, Tong Cheng, Jun Zhang*, Tianying Zhang*, Huachen Zhu*,Qinjian Zhao*, Quan Yuan*, Yi Guan*, Ningshao Xia*. A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters. Science Translational Medicine. 2021, 13(606):eabg1143. DOI: 10.1126/scitranslmed.abg1143.

  2. Xin Wang, Xiaochen Yin, Boya Zhang, Chenfeng Liu, Yahua Lin, Xiaofen Huang, Yufang Li, Chenguang Shen, Weibin Zheng, Guofeng Fu, Junyu Chen, Yanling Wen, Wei Zhang, Bo-Sheng Pan, Mujin Fang, Zizheng Zheng, Zheng Zhang, Quan Yuan, Guo Fu, Jun Zhang, Yixin Chen, Ningshao Xia,Qinjian Zhao*. A prophylactic effect of aluminum-based adjuvants against respiratory viruses via priming local innate immunity. Emerging Microbes & Infections. 2022. DOI: 10.1080/22221751.2022.2050951.

  3. Xinyuan Zhang, Zhigang Zhang, Ningshao Xia,Qinjian Zhao*. Carbohydrate-containing nanoparticles as vaccine adjuvants. Expert Review of Vaccines. 2021, 20(7):797-810.

  4. Xiaofen Huang, Yike Li, Meifeng Nie, Mingxi Yue, Yufang Li, Zhijie Lin, Huirong Pan, Mujin Fang, Ting Wu, Shaowei Li, Jun Zhang, Ningshao Xia*, Qinjian Zhao∗. Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal. Journal of Pharmaceutical Analysis. 2021, 11(5):617-627.

  5. Xiao Zhang, Bingchun Zhao, Mingmei Ding, Shuo Song, Yinfeng Kang, Yang Yu, Miao Xu, Tong Xiang, Ling Gao, Qisheng Feng,Qinjian Zhao*, Mu-Sheng Zeng*, Claude Krummenacher, Yi-Xin Zeng*. A novel vaccine candidate based on chimeric virus-like particle displaying multiple conserved epitope peptides induced neutralizing antibodies against EBV infection. Theranostics. 2020, 10(13): 5704-5718.

  6. Lijie Ren, Zhigang Zhang, Xinyuan Zhang, Zhibo Kong, Shaowei Li,Qinjian Zhao*. In situ analysis of biomolecular interactions on nano/microparticles in formulations. Journal of Pharmaceutical and Biomedical Analysis. 2021, 201:114130.

  7. Bin He, Zhigang Zhang, Xinyuan Zhang, Ziming Tang, Chang Liu, Zizheng Zheng, Shaowei Li, Jun Zhang, Ningshao Xia,Qinjian Zhao*. Functional epitopes on hepatitis E virions and recombinant capsids are highly comformation-dependent. Human Vaccines & Immunotherapeutics. 2020, 16(7):1554-1564.

  8. Yike Li, Xiaofen Huang, Zhigang Zhang, Shaowei Li, Jun Zhang, Ningshao Xia,Qinjian Zhao*. Prophylactic hepatitis E vaccines: antigenic analysis and serological evaluation. Viruses. 2020, 12(1):109.

  9. Xiaochen Yin, Xin Wang, Zhigang Zhang, Yufang Li, Zhijie Lin, Huirong Pan, Ying Gu, Shaowei Li, Jun Zhang, Ningshao Xia*,Qinjian Zhao*. Demonstration of real-time and accelerated stability of hepatitis E vaccine with a combination of different physicochemical and immunochemical methods. Journal of Pharmaceutical and Biomedical Analysis. 2020, 177:112880.

  10. Zhigang Zhang, Tianying Zhang, Lu Cao, Xin Wang, Jiali Cao, Xiaofen Huang, Yashuang Cai, Zhijie Lin, Huirong Pan, Quan Yuan, Mujin Fang, Shaowei Li, Jun Zhang, Ningshao Xia,Qinjian Zhao*. Simultaneous in situ visualization and quantitation of dual antigens adsorbed on adjuvants using high content analysis. Nanomedicine. 2019, 14(19):2535-2548.

  11. Siyi Chen, Xiaofen Huang, Yike Li, Xin Wang, Huirong Pan, Zhijie Lin, Qingbing Zheng, Shaowei Li, Jun Zhang, Ningshao Xia*,Qinjian Zhao*. Altered antigenicity and immunogenicity of human papillomavirus virus-like particles in the presence of thimerosal. European Journal of Pharmaceutics and Biopharmaceutics. 2019, 141:221-231.

  12. Kaihang Wang⁠, Lizhi Zhou⁠, Xiao Zhang⁠, Cuiling Song⁠, Tingting Chen⁠, Jiajia Li⁠, Minghua Zheng⁠, Yingbin Wang, Qingbing Zheng⁠, Zizheng Zheng⁠, Hai Yu⁠, Ting Wu⁠, Ying Gu, Jun Zhang⁠,Qinjian Zhao⁠*, Shaowei Li⁠⁠*, Ningshao Xia. Hepatitis E vaccine candidate harboring a non-particulate immunogen of E2 fused with CRM197 fragment A. Antiviral Research. 2019, 164:154-161.

  13. Xin Wang, Min Li, Zhijie Lin, Huirong Pan, Zimin Tang, Zizheng Zheng, Shaowei Li, Jun Zhang, Ningshao Xia*,Qinjian Zhao*. Multifaceted characterization of recombinant protein-based vaccines: An immunochemical toolbox for epitope-specific analyses of the hepatitis E vaccine. Vaccine. 2018, 36(50):7650-7658.

  14. Cai Zhang, Xiaofen Huang, Siyi Chen, Yike Li, Yufang Li, Xin Wang, Jixian Tang, Lin Xia, Zhijie Lin, Wenxin Luo, Tingdong Li, Shaowei Li, Jun Zhang, Ningshao Xia*,Qinjian Zhao*. Epitope clustering analysis for vaccine-induced human antibodies in relationship to a panel of murine monoclonal antibodies against HPV16 viral capsid. Vaccine. 2018, 36(45):6761-6771.

  15. Zhigang Zhang, Jun Zhang, Ningshao Xia,Qinjian Zhao*. Expanded strain coverage for a highly successful public health tool: Prophylactic 9-valent human papillomavirus vaccine. Human Vaccines & Immunotherapeutics. 2017, 13(10):2280-2291.

  16. Xin Wang, Zhiqiang An, Wenxin Luo, Ningshao Xia,Qinjian Zhao*. Molecular and functional analysis of monoclonal antibodies in support of biologics development. Protein & Cell. 2017. 9(1):74–85.

  17. Yahua Lin, Xin Wang, Xiaofen Huang, Jun Zhang, Ningshao Xia,Qinjian Zhao*. Calcium phosphate nanoparticles as a new generation vaccine adjuvant. Expert Review of Vaccines. 2017, 16(9):895-906.

  18. Xiaofen Huang, Xin Wang, Jun Zhang, Ningshao Xia, Qinjian Zhao*. Escherichia coli-derived virus-like particles in vaccine development. npj Vaccines. 2017, 2:3. DOI: 10.1038/s41541-017-0006-8..

  19. Zhang X, Wei M, Sun G, Wang X, Li M, Lin Z, Li Z, Li Y, Fang M, Zhang J, Li S, Xia N*,Zhao Q*. Vaccine. Real-time stability of a hepatitis E vaccine (Hecolin®) demonstrated with potency assays and multifaceted physicochemical methods. Vaccine, 2016, 34(48):5871-5877.

  20. Lu Cao, Xin Wang, Mujin Fang, Ningshao Xia,Qinjian Zhao*. Detection of subtle differences in analogous viral capsid proteins by allowing unrestricted specific interaction in solution competition ELISA. Journal of Virological Methods, 2016, 236: 1-4.

  21. Min Li, Xin Wang, Lu Cao, Zhijie Lin, Minxi Wei, Mujin Fang, Shaowei Li, Jun Zhang, Ningshao Xia*,Qinjian Zhao*. Quantitative and epitope-specific antigenicity analysis of the human papillomavirus 6 capsid protein in aqueous solution or when adsorbed on particulate adjuvants. Vaccine, 2016, 34(37): 4422-4428.

  22. Qingshan Lin, Kunyu Yang, Fangping He, Jie Jiang, Tingting Li, Zhenqin Chen, Rui Li, Yixin Chen, Shaowei Li*,Qinjian Zhao*, Ningshao Xia. Production of Influenza Virus HA1 Harboring Native-Like Epitopes by Pichia pastoris. Applied Biochemistry and Biotechnology, 2016, 179(7): 1275–1289.

  23. Lin Xia#, Yangfei Xian#, Daning Wang, Yuanzhi Chen, Xiaofen Huang, Xingjian Bi, Hai Yu, Zheng Fu, Xinlin Liu, Shaowei Li, Zhiqiang An, Wenxin Luo*,Qinjian Zhao*, Ningshao Xia. A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5. Scientific Report, 2016, 6: 19042.

  24. Xiao Zhang, Shaowei Li, Yorgo Modis, Zhihai Li, Jun Zhang, Ningshao Xia*,Qinjian Zhao*. Functional assessment and structural basis of antibody binding to human papillomavirus capsid. Review in Medical Virology, 2016, 26:115-128.

  25. Xin Wang, Min Li, Shaowei Li, Ting Wu, Jun Zhang, Ningshao Xia*,Qinjian Zhao*. Prophylaxis against Hepatitis E: at risk populations and human vaccines. Expert review of vaccines, 2016, 15(7): 815-827.

上一篇:陈永洁
下一篇:赵倩倩

Copyright © 2019 All Rights Reserved

版权所有 © 重庆医科大学beat365手机中文官方网站 / 地址:重庆市渝中区医学院路1号 / 邮政编码:400016