10):NatureCommunications(IF 14.9),J. Am. Chem. Soc. (IF 14.6),ACS Catalysis(IF 12.2)。教育背景南洋理..." />

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颜建明

作者:时间:2021-11-04点击数:

颜建明,特聘教授,硕士研究生导师。新加坡南洋理工大学博士(2018),新加坡国立大学博士后(2018-2021,合作导师:吴杰)

联系方式:yanjianming1@hotmail.com103111@cqmu.edu.cn

近年来,在药物合成化学领域取得了丰富的科研成果,以第一作者身份发表高水平论文(JCR-1区)6篇,包括3篇顶级期刊论文(影响因子IF>10):NatureCommunications(IF 14.9),J. Am. Chem. Soc. (IF 14.6),ACS Catalysis(IF 12.2)。

教育背景

南洋理工大学(新加坡) 有机化学博士(导师Prof. Naohiko Yoshikai, 2013.8–2017.8)

中国科学院上海药物研究所 药物化学硕士(导师胡立宏研究员(杰青), 2010.9–2013.7)

中国药科大学(211工程) 药物化学学士(2006.9–2010.7)

研究方向

1.可见光化学催化的药物合成绿色方法。

2.选择性C-H活化开发新颖的药物后期官能团化方法。

3.光化学和新型连续流装置的辅助下发展绿色药物合成工艺。

研究论文

  1. Jianming Yan, HaidiTang, Xiangcheng Shi, Eugene Jun Rong Kuek,Chenguang Liu, Muliang Zhang, Jared L. Piper, Shengquan Duan, Jie Wu.Divergent Functionalization of Aldehydes Photocatalyzed by Neutral Eosin Y with Sulfone Reagents.NatureCommunications.2021,12. 7214.(IF 14.9,1区,2021-Top 25Chemistry and Materials Sciences Articles inNature Communications)DOI:10.1038/s41467-021-27550-8

  2. Jianming Yan, Han Wen Cheo, Wei Kiat Teo, Xiangcheng Shi, Hui Wu, Shabana Binte Idres, Lih-Wen Deng, Jie Wu. A Radical Smiles Rearrangement Promoted by Neutral Eosin Y as a Direct Hydrogen Atom Transfer Photocatalyst.J. Am. Chem. Soc.2020,142, 11357–11362.(IF 14.6,1区).https://pubs.acs.org/doi/10.1021/jacs.0c02052

  3. Jianming Yan,Md. Shafiqur Rahman, Naohiko Yoshikai Pd-Catalyzed Annulation of 1-Halo-8-arylnaphthalenes and Alkynes Leading to Heptagon-Embedded Aromatic Systems.Chemistry – A European Journal2019,25, 9395–9399.(IF 4.9;2区).10.1002/chem.201805746

  4. Jianming Yan, Naohiko Yoshikai. Phenanthrene Synthesis via Chromium-Catalyzed Annulation of 2-Biaryl Grignard Reagents and Alkynes.Org. Lett.2017,19, 6630–6633. (IF 6.6;1区).DOI:10.1021/acs.orglett.7b03342

  5. JianmingYan,Naohiko Yoshikai.Chromium-CatalyzedMigratory Arylmagnesiation of Unactivated Alkynes.Org. Chem. Front.2017,4, 1972–1975.(IF 5.1;1区).DOI:10.1039/C7QO00427C

  6. Jianming Yan,Naohiko Yoshikai. Cobalt-Catalyzed Arylative Cyclization of Acetylenic Esters and Ketones with Arylzinc Reagents through 1,4-Cobalt Migration.ACS Catal.2016,6, 3738–3742.(IF 12.2;1区).DOI:10.1021/acscatal.6b01039

  7. Jianming Yan, Guan Liang Tay, Cuien Neo, Bo Ra Lee, and Philip Wai Hong Chan. Gold-Catalyzed Cycloisomerization and Diels–Alder Reaction of 1,6-Diyne Esters with Alkenes and Diazenes to Hydronaphthalenes and –cinnolines.Org. Lett.2015,17, 4176–4179.(IF 6.6;1区). DOI:10.1021/acs.orglett.5b01935

  8. Jianming Yan, Min Lei, Lihong Hu. Simple and Efficient Method for the Synthesis of 1-((Aryl)(2-oxindolin-3-yl-)mehyl)urea and 1-((Aryl)(2-oxindolin-3-yl-)mehyl)thiourea Derivatives.Synth. Commun.2014,44, 127–132.(IF 1.1;4区).DOI:10.1080/00397911.2013.794362

  9. Zhiyuan Zhu,Jianming Yan, Wei Jiang, Xin-gang Yao, Jing Chen, Lili Chen, Chenjing Li, Lihong Hu, Hualiang Jiang, Xu Shen. Arctigenin Effectively Ameliorates Memory Impairment in AD Model Mice Targeting both Aβ Production and Clearance.J. Neurosci.2013, 33, 13138–13149.(IF 5.9;1区).DOI:10.1523/JNEUROSCI.4790-12.2013

  10. Xingyu Xu, Chong Li, Min Lei, Zhiyuan Zhu,Jianming Yan,Xu Shen, Lihong Hu. Synthesis and Decreasing Aβ Content Evaluation of Arctigenin-4-yl Carbamate Derivatives.Bioorg. Med. Chem. Lett.2016,26, 2988–2991.(IF 2.5;3区).

    DOI:10.1016/j.bmcl.2016.05.028.

  11. Han Wang, Haiwang Liu, Mu Wang, Meirong Huang, Xiangcheng Shi, Tonglin Wang, Xu Cong,Jianming Yan,Jie Wu.Bromine Radical as a Visible-light-mediated Polarity-reversal Catalyst.iScience,2021, 102693. (IF 5.5;1区). DOI:https://doi.org/10.1016/j.isci.2021.102693

  12. Xuanzi Fan , Muliang Zhang , Qi Zhou , Yanbin Zhang , Yuanjun Gao , Jiajia Yu , Wengang Xu ,Jianming Yan, Haiwang Liu , Zhexuan Lei , Yan Chong Ter , Supphachok Chanmungkalakul , Xiaogang Liu, Ganglong Cui,Jie Wu.Stepwise On-Demand Functionalization of Multihydrosilanes Enabled by Eosin Y-Based Hydrogen Atom Transfer Photocatalysis.2022,NatureChemistry(under revision).

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