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马玉莹

作者:时间:2021-10-20点击数:

马玉莹,女,特聘副教授,硕士生导师。

邮箱:yuying_ma@cqmu.edu.cn

教育工作经历:

2010.09-2014.06辽宁大学beat365手机中文官方网站,制药工程专业,工学学士

2014.09-2019.06南开大学beat365手机中文官方网站,化学生物学专业,理学博士(导师:尹正教授、尚鲁庆教授)

2019.08-2021.06美国Texas A&M大学化学院,药物化学方向,博士后研究人员(合作导师:Prof.WensheR. Liu)

2021.09-至今重庆医科大学beat365手机中文官方网站,药物化学系,特聘副教授,硕士生导师

研究方向:

1.抗病毒的小分子药物开发与优化

2.蛋白降解策略在欠开发靶标上的应用

3.具有抗肿瘤活性的天然产物衍生物的优化

代表性科研成果:

1.Y. Ma, L. Li, S. He, C. Shang, Y. Sun, N. Liu, T. D. Meek, Y. Wang, L. Shang. Application of dually activated Michael acceptor to the rational design of reversible covalent inhibitor for enterovirus 71 3C protease.Journal of Medicinal Chemistry, 2019, 62(13), 6146-6162. (IF=7.446,一区)

2.Y. Ma, C. Shang, P. Yang, L. Li,Y. Zhai, Z. Yin, B. Wang, L. Shang. 4-Iminooxazolidin-2-one as a bioisostere of the cyanohydrin moiety: inhibitors of Enterovirus 71 3C protease.Journal of Medicinal Chemistry, 2018, 61(22), 10333-10339. (IF=7.446,一区)

3.K.S. Yang, X.R. Ma,Y. Ma, Y.R. Alugubelli, D.A. Scott, E.C. Vatansever, A.K. Drelich, B. Sankaran, Z.Z. Geng, L.R. Blankenship, H.E. Ward, Y.J. Sheng, J.C. Hsu, K.C. Kratch, B. Zhao, H.S. Hayatshahi, J. Liu, P. Li, C.A. Fierke, C.‐T.K. Tseng, S. Xu, and W.R. Liu, A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors.ChemMedChem, 2021, 16, 942–948. (IF=3.124,共同一作)

4.Y. Zhai,Y. Ma, F. Ma, Q. Nie, X. Ren, Y. Wang, L. Shang, Z. Yin, Structure-activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors,Eur. J. Med. Chem., 124 (2016) 559-573. (IF=6.514,一区)

5.D. Zeng,Y. Ma, R. Zhang, Q. Nie, Z. Cui, Y. Wang, L. Shang, Z. Yin, Synthesis and structure-activity relationship of alpha-keto amides as enterovirus 71 3C protease inhibitors,Bioorg. Med. Chem. Lett., 26 (2016) 1762-1766. (IF=2.823)

6.M. Liu, B. Xu,Y. Ma, L. Shang, S. Ye, Y. Wang. Reversible covalent inhibitors suppress enterovirus 71 infection by targeting the 3C protease.Antiviral Research, 192 (2021) 105102. (IF=5.970)

7.S. Fu, Q. Nie,Y. Ma, P. Song, X. Ren, C. Luo, L. Shang, Z. Yin, Target-guided screening of fragments (TGSOF) in the discovery of inhibitors against EV-A71 3C protease,Chem. Commun. (Camb.), 54 (2018) 2890-2893. (IF=6.222)

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