马玉莹，女，特聘副教授，硕士生导师。

邮箱：yuying_ma@cqmu.edu.cn

教育工作经历：

2010.09-2014.06辽宁大学beat365手机中文官方网站，制药工程专业，工学学士

2014.09-2019.06南开大学beat365手机中文官方网站，化学生物学专业，理学博士（导师：尹正教授、尚鲁庆教授）

2019.08-2021.06美国Texas A&M大学化学院，药物化学方向，博士后研究人员（合作导师：Prof.WensheR. Liu）

2021.09-至今重庆医科大学beat365手机中文官方网站，药物化学系，特聘副教授，硕士生导师

研究方向：

1.抗病毒的小分子药物开发与优化

2.蛋白降解策略在欠开发靶标上的应用

3.具有抗肿瘤活性的天然产物衍生物的优化

代表性科研成果：

1.Y. Ma, L. Li, S. He, C. Shang, Y. Sun, N. Liu, T. D. Meek, Y. Wang, L. Shang. Application of dually activated Michael acceptor to the rational design of reversible covalent inhibitor for enterovirus 71 3C protease.Journal of Medicinal Chemistry, 2019, 62(13), 6146-6162. (IF=7.446,一区)

2.Y. Ma, C. Shang, P. Yang, L. Li,Y. Zhai, Z. Yin, B. Wang, L. Shang. 4-Iminooxazolidin-2-one as a bioisostere of the cyanohydrin moiety: inhibitors of Enterovirus 71 3C protease.Journal of Medicinal Chemistry, 2018, 61(22), 10333-10339. (IF=7.446,一区)

3.K.S. Yang, X.R. Ma,Y. Ma, Y.R. Alugubelli, D.A. Scott, E.C. Vatansever, A.K. Drelich, B. Sankaran, Z.Z. Geng, L.R. Blankenship, H.E. Ward, Y.J. Sheng, J.C. Hsu, K.C. Kratch, B. Zhao, H.S. Hayatshahi, J. Liu, P. Li, C.A. Fierke, C.‐T.K. Tseng, S. Xu, and W.R. Liu, A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors.ChemMedChem, 2021, 16, 942–948. (IF=3.124,共同一作)

4.Y. Zhai,Y. Ma, F. Ma, Q. Nie, X. Ren, Y. Wang, L. Shang, Z. Yin, Structure-activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors,Eur. J. Med. Chem., 124 (2016) 559-573. (IF=6.514,一区)

5.D. Zeng,Y. Ma, R. Zhang, Q. Nie, Z. Cui, Y. Wang, L. Shang, Z. Yin, Synthesis and structure-activity relationship of alpha-keto amides as enterovirus 71 3C protease inhibitors,Bioorg. Med. Chem. Lett., 26 (2016) 1762-1766. (IF=2.823)

6.M. Liu, B. Xu,Y. Ma, L. Shang, S. Ye, Y. Wang. Reversible covalent inhibitors suppress enterovirus 71 infection by targeting the 3C protease.Antiviral Research, 192 (2021) 105102. (IF=5.970)

7.S. Fu, Q. Nie,Y. Ma, P. Song, X. Ren, C. Luo, L. Shang, Z. Yin, Target-guided screening of fragments (TGSOF) in the discovery of inhibitors against EV-A71 3C protease,Chem. Commun. (Camb.), 54 (2018) 2890-2893. (IF=6.222)